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eBook details

• Title: Effects of Dietary Alpha-Lipoic Acid on Anti-Oxidative Ability and Meat Quality in Arbor Acres Broilers (Report)
• Author : Asian - Australasian Journal of Animal Sciences
• Release Date : January 01, 2009
• Genre: Industries & Professions,Books,Business & Personal Finance,
• Pages : * pages
• Size : 290 KB

Description

INTRODUCTION Alpha-lipoic acid (LA) and its reduced form, dihydrolipoic acid (DHLA), have received widespread attention as antioxidants with both preventative and therapeutic uses in humans and laboratory animals. LA is an antioxidant and exogenously supplied LA can be NADH and NADPH-dependently reduced in mitochondria and cytosol (Haramaki et al., 1997). LA has been shown to act as an NADH oxidase inhibitor to block oxidant production and decrease phagocytosis of myelin by macrophages (Goes et al., 1998). The thiol compound lipoic acid and its reduced form dihydrolipoic acid are able to scavenge various reactive oxygen species. Moreover, the lipoic acid redox couple is capable of recycling other antioxidants such as vitamin E, vitamin C, and GSH, thus forming a socalled "antioxidant defense network". In addition, LA has been shown to be effective in upregulation of the intracellular GSH content of lymphocytes (Sen et al., 1997). LA is a coenzyme involved in mitochondrial metabolism. The reduced form of LA, dihydrolipoic acid, is a powerful mitochondrial antioxidant (Packer et al., 1997a; b; Moini et al., 2002). Dietary administration of LA elicits fatty acid mobilization in p-adrenergic response to isoproterenol when the basal level of plasma glucose is maintained (Hamano et al., 2000). LA is a mitochondrial nutrient and it is also one of the mostly studied mitochondrial nutrients on mitochondrial function in cellular and animal models related to brain aging and neurodegeneration (Liu, 2008).

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