[DOWNLOAD] ~ Effects of [Beta]-Glucan from Paenibacillus Polymyxa and L-Theanine on Growth Performance and Immunomodulation in Weanling Piglets (Report) " by Asian - Australasian Journal of Animal Sciences ~ Book PDF Kindle ePub Free

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• Title: Effects of [Beta]-Glucan from Paenibacillus Polymyxa and L-Theanine on Growth Performance and Immunomodulation in Weanling Piglets (Report)
• Author : Asian - Australasian Journal of Animal Sciences
• Release Date : January 01, 2008
• Genre: Industries & Professions,Books,Business & Personal Finance,
• Pages : * pages
• Size : 308 KB

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ABSTRACT : Forty weanling piglets (5.6 [+ or -] 0.5 kg and 26 to 30 d of age) were used in a 28-d experiment to determine the effects of [beta]-glucan from Paenibacillus polymyxa and L-theanine on growth performance. Piglets were randomly allotted to four groups (n = 10, 2 animals per pen) provided with the basal feed (control), [beta]-glucan 400 mg/kg feed, L-theanine 80 mg/kg feed or [beta]-glucan plus l-theanine (combination of the above-mentioned concentrations). Body weight and feed consumption were recorded during four weeks. Subsequently, the immunomodulatory effects of [beta]-glucan and L-theanine were investigated for lipopolysaccharide (LPS)-induced cytokine production in vitro and in vivo on day 28. Although there were no significant differences in the growth performances among the treatment groups, [beta]-glucan plus L-theanine had 5.6% greater ADG (p = 0.074) on day 21 to 28. [beta]-Glucan alone or plus L-theanine increased interleukin (IL)-10 levels and decreased interferon (IFN)-[gamma] and tumor necrosis factor (TNF)-a levels in cultured medium by LPS treatment (p0.05). Plasma IL-10 levels were also increased in the piglets fed with [beta]-glucan alone or plus L-theanine after LPS challenge (25 [micro]g/kg, i.p.), whereas plasma IFN-[gamma] and TNF-[alpha] levels were decreased (p0.05). The levels of IFN-[gamma] in piglets fed with [beta]-glucan plus L-theanine showed the greatest inhibition after LPS challenges. In conclusion, treatment of [beta]-glucan alone or plus L-theanine might lessen inflammatory responses against Gram-negative bacterial infection via the inhibition of pro-inflammatory cytokine production and enhancement of anti-inflammatory cytokine production. Further studies are needed to determine an optimal concentration of [beta]-glucan and L-theanine for improved growth performance. (Key Words : [beta]-Glucan, L-theanine, Piglets, Lipopolysaccharide, Cytokine) INTRODUCTION

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